Leptin–STAT3–G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression
نویسندگان
چکیده
منابع مشابه
Leptin-STAT3-G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression.
Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Here we report how leptin, an obesity-associated adipokine, regulates a transcriptional pathway to silence a genetic program of epithelial homeostasis in breast cancer stem-like cells (CSC) that promotes malignant progression. Using genome-wide ChIP-seq and RNA expression profiling, we defined a r...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2015
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-14-3076